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Lung metastases

Definition

Lung metastases are cancerous tumors that start somewhere else in the body and spread to the lungs.

Causes

Metastatic tumors in the lungs are cancers that developed at other places in the body (or other parts of the lungs). They then spread through the bloodstream or lymphatic system to the lungs. It is different than lung cancer that starts in the lungs.

Nearly any cancer can spread to the lungs. Common cancers include:

• Bladder cancer

• Breast cancer

• Lung cancer

• Colorectal cancer

• Kidney cancer

• Melanoma

• Ovarian cancer

• Sarcoma

• Thyroid cancer

• Pancreatic cancer

• Testicular cancer

Symptoms

Symptoms may include any of the following:

• Bloody sputum

• Chest pain

• Cough

• Shortness of breath

• Weakness

• Weight loss

Exams and Tests

Your health care provider will examine you and ask about your medical history and symptoms. Tests that may be done include:

• Bronchoscopy to view the airways and take tissue samples, if possible

• Chest CT scan

• Chest x-ray

• Cytologic studies of pleural fluid or sputum

• Lung needle biopsy

• PET scan

• Surgery to take a sample of tissue from the lungs (surgical lung biopsy)

Treatment

Chemotherapy is often used to treat metastatic cancer to the lung. Surgery to remove the tumors may be done when any of the following occurs:

• The cancer has spread to only limited areas of the lung

• The lung tumors can be completely removed with surgery

However, the main tumor must be curable, and the person must be strong enough to go through the surgery and recovery.

Other treatments include:

• Radiation therapy

• Immunotherapy

• Targeted systemic therapy

• The placement of stents inside the airways

• Laser therapy

• Using local heat probes to destroy the cancer

• Using very cold temperature to destroy the cancer

Support Groups

You can ease the stress of illness by joining a support group where members share common experiences and problems.

Outlook (Prognosis)

A cure is unlikely in most cases of cancers that have spread to the lungs. But the outlook depends on the main cancer. In some cases, a person can live more than 5 years with metastatic cancer to the lungs.

Possible Complications

Complications of metastatic tumors in the lungs may include:

• Fluid between the lung and chest wall (pleural effusion), which can cause shortness of breath or pain when taking a deep breath

• Further spread of the cancer

When to Contact a Medical Professional

Contact your provider if you have a history of cancer and you develop:

• Coughing up blood

• Persistent cough

• Shortness of breath

• Unexplained weight loss

Prevention

Not all cancers can be prevented. However, many can be prevented by:

• Eating healthy foods

• Exercising regularly

• Limiting alcohol consumption

• Not smoking

References

Arenberg DA, Reddy RM. Metastatic malignant tumors. In: Broaddus VC, Ernst JD, King TE, et al, eds. Murray and Nadel's Textbook of Respiratory Medicine. 7th ed. Philadelphia, PA: Elsevier; 2022:chap 79.

Hayman J, Naidoo J, Ettinger DS. Lung metastases. In: Niederhuber JE, Armitage JO, Kastan MB, Doroshow JH, Tepper JE, eds. Abeloff's Clinical Oncology. 6th ed. Philadelphia, PA: Elsevier; 2020:chap 57.

Wald O, Izhar U, Sugarbaker DJ. Lung, chest wall, pleura, and mediastinum. In: Townsend CM Jr, Beauchamp RD, Evers BM, Mattox KL, eds. Sabiston Textbook of Surgery. 21st ed. St Louis, MO: Elsevier; 2022:chap 58.

Review Date: 6/17/2024

Reviewed By: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.