Multiple mononeuropathy
Multiple mononeuropathy is a nervous system disorder that involves damage to at least two separate nerve areas. Neuropathy means damage to a peripheral nerve.
Causes
Multiple mononeuropathy is due to damage to one or more peripheral nerves. These are the nerves outside the brain and spinal cord. It is a group of symptoms (syndrome), not a disease.
However, certain diseases can cause the injury or nerve damage that leads to the symptoms of multiple mononeuropathy. Common conditions include:
- Blood vessel diseases such as polyarteritis nodosa
- Connective tissue diseases such as rheumatoid arthritis or systemic lupus erythematosus (the most common cause in children)
- Diabetes
Diabetes
Diabetes is a long-term (chronic) disease in which the body cannot regulate the amount of sugar in the blood.
ImageRead Article Now Book Mark Article - Hereditary causes that predispose to nerve injury (such as hereditary neuropathy with liability to pressure palsy)
Less common causes include:
- Amyloidosis, an abnormal buildup of proteins in tissues and organs
- Blood disorders (such as hypereosinophilia and cryoglobulinemia)
- Infections such as Lyme disease, HIV/AIDS, or hepatitis
Lyme disease
Lyme disease is a bacterial infection that is spread through the bite of one of several types of ticks.
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- Sarcoidosis, which also may cause inflammation of the lymph nodes, lungs, liver, eyes, skin, or other tissues
- Sjögren syndrome, a disorder in which the glands that produce tears and saliva are destroyed
- Granulomatosis with polyangiitis, an inflammation of the blood vessel
Symptoms
Symptoms depend on the specific nerves involved, and may include:
- Loss of bladder or bowel control
- Loss of sensation in one or more areas of the body
- Paralysis in one or more areas of the body
Paralysis
Muscle function loss is when a muscle does not work or move normally. The medical term for complete loss of muscle function is paralysis.
ImageRead Article Now Book Mark Article - Tingling, burning, pain, or other abnormal sensations in one or more areas of the body
- Weakness in one or more areas of the body
Exams and Tests
Your health care provider will perform a physical exam and ask about the symptoms, focusing on the nervous system.
To diagnose this syndrome, there usually needs to be problems with two or more unrelated nerve areas. Common nerves affected are the:
- Axillary nerve in either arm or shoulder
Axillary nerve
Axillary nerve dysfunction is nerve damage that can lead to a loss of movement or sensation in the shoulder.
ImageRead Article Now Book Mark Article - Common peroneal nerve in the lower leg
Common peroneal nerve
Common peroneal nerve dysfunction is due to damage to the peroneal nerve leading to loss of movement or sensation in the foot and leg. This conditio...
ImageRead Article Now Book Mark Article - Distal median nerve to the hand
Distal median nerve
Distal median nerve dysfunction is a form of peripheral neuropathy that affects the movement of or sensation in the hands. A common type of distal me...
ImageRead Article Now Book Mark Article - Femoral nerve in the thigh
Femoral nerve
Femoral nerve dysfunction is a loss of movement or sensation in parts of the legs due to damage to the femoral nerve.
ImageRead Article Now Book Mark Article - Radial nerve in the arm
Radial nerve
Radial nerve dysfunction is a problem with the radial nerve. This is the nerve that travels from the armpit down the back of the arm to the hand. I...
ImageRead Article Now Book Mark Article - Sciatic nerve in the back of the leg
Sciatic nerve
Sciatica refers to pain, weakness, numbness, or tingling in the leg. It is caused by injury to or pressure on the sciatic nerve. Sciatica is a symp...
ImageRead Article Now Book Mark Article - Ulnar nerve in the arm
Ulnar nerve
Ulnar nerve dysfunction is a problem with one of the nerves that travel from the shoulder to the hand, called the ulnar nerve. It helps you move you...
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Tests may include:
- Electromyogram (EMG, a recording of electrical activity in the muscles)
Electromyogram
Electromyography (EMG) is a test that checks the health of the muscles and the nerves that control the muscles.
ImageRead Article Now Book Mark Article - Nerve biopsy to examine a piece of the nerve under a microscope
Nerve biopsy
A nerve biopsy is the removal of a small piece of a nerve for examination.
ImageRead Article Now Book Mark Article - Nerve conduction tests to measure how fast nerve impulses move along the nerve
Nerve conduction tests
Nerve conduction velocity (NCV) is a test to see how fast electrical signals move through a nerve. This test is done along with electromyography (EM...
ImageRead Article Now Book Mark Article - Imaging tests, such as x-rays
Blood tests that may be done include:
- Antinuclear antibody panel (ANA)
- Blood chemistry tests
- C-reactive protein
- Imaging scans
- Pregnancy test
- Rheumatoid factor
- Sedimentation rate
- Thyroid tests
- X-rays
Treatment
The goals of treatment are to:
- Treat the illness that is causing the problem, if possible
- Provide supportive care to maintain independence
- Control symptoms
To improve independence, treatments may include:
- Occupational therapy
- Orthopedic help (for example, a wheelchair, braces, and splints)
- Physical therapy (for example, exercises and retraining to increase muscle strength)
- Vocational therapy
Safety is important for people with sensation or movement problems. Lack of muscle control and decreased sensation may increase the risk for falls or injuries. Safety measures include:
- Having adequate lighting (such as leaving lights on at night)
- Installing railings
- Removing obstacles (such as loose rugs that may slip on the floor)
- Testing water temperature before bathing
- Wearing protective shoes (no open toes or high heels)
Check shoes often for grit or rough spots that may injure the feet.
People with decreased sensation should check their feet (or other affected area) often for bruises, open skin areas, or other injuries that may go unnoticed. These injuries may become severely damaged or infected because the pain nerves of the area are not signaling the injury.
People with multiple mononeuropathy may be prone to new nerve injuries at pressure points such as the knees and elbows. They should avoid putting pressure on these areas, for example, by not leaning on the elbows, crossing the knees, or holding similar positions for long periods. Some people may benefit from pads on the elbows or knees.
Medicines that may help include:
- Over-the-counter or prescription pain medicines
- Antiseizure or antidepressant medicines to reduce stabbing pains
Depending on the cause, surgery may be recommended to reduce pressure on nerves.
Outlook (Prognosis)
A full recovery is possible if the cause is found and treated, and if the nerve damage is limited. Some people have no disability. Others have a partial or complete loss of movement, function, or sensation.
Possible Complications
Complications may include:
- Deformity, loss of tissue or muscle mass
- Disturbances of organ functions
- Medicine side effects
- Repeated or unnoticed injury to the affected area due to lack of sensation
- Relationship problems due to erectile dysfunction
Erectile dysfunction
An erection problem occurs when a man cannot get or keep an erection that is firm enough for intercourse. You may not be able to get an erection at ...
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When to Contact a Medical Professional
Contact your provider if you notice signs of multiple mononeuropathy.
Prevention
Preventive measures depend on the specific disorder. For example, with diabetes, eating healthy foods and keeping a tight control of blood sugar may help prevent multiple mononeuropathy from developing.
Reviewed By
Joseph V. Campellone, MD, Department of Neurology, Cooper Medical School at Rowan University, Camden, NJ. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
Katirji B. Disorders of peripheral nerves. In: Jankovic J, Mazziotta JC, Pomeroy SL, Newman NJ, eds. Bradley and Daroff's Neurology in Clinical Practice. 8th ed. Philadelphia, PA: Elsevier; 2022:chap 106.
Smith AG, Shy ME. Peripheral neuropathies. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 388.
