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HCG blood test - quantitative

Definition

A quantitative human chorionic gonadotropin (HCG or hCG) blood test measures the specific level of HCG in the blood. HCG is a hormone produced in the body during pregnancy.

Other HCG tests include:

• HCG urine test

• HCG blood test -- qualitative

How the Test is Performed

A blood sample is needed. This is most often taken from a vein. The procedure is called a venipuncture.

How to Prepare for the Test

No special preparation is needed.

How the Test will Feel

When the needle is inserted to draw blood, some people feel moderate pain. Others feel only a prick or stinging sensation. Afterward, there may be some throbbing.

Why the Test is Performed

HCG appears in the blood and urine of pregnant women as early as 10 days after conception. Quantitative HCG measurement helps determine the exact age of the fetus. It can also assist in the diagnosis of abnormal pregnancies, such as ectopic pregnancies, molar pregnancies, and possible miscarriages. It is also used as part of a screening test for Down syndrome.

This test is also done to diagnose abnormal conditions not related to pregnancy that can raise HCG level.

Normal Results

Results are given in milli-international units per milliliter (mUI/mL).

Normal levels are found in:

• Non-pregnant women: less than 5 mIU/mL

• Healthy men: less than 2 mIU/mL

In pregnancy, HCG level rises rapidly during the first trimester and then declines slightly. The expected HCG ranges in pregnant women are based on the length of the pregnancy.

• 3 weeks: 5 - 72 mIU/mL

• 4 weeks: 10 -708 mIU/mL

• 5 weeks: 217 - 8,245 mIU/mL

• 6 weeks: 152 - 32,177 mIU/mL

• 7 weeks: 4,059 - 153,767 mIU/mL

• 8 weeks: 31,366 - 149,094 mIU/mL

• 9 weeks: 59,109 - 135,901 mIU/mL

• 10 weeks: 44,186 - 170,409 mIU/mL

• 12 weeks: 27,107 - 201,165 mIU/mL

• 14 weeks: 24,302 - 93,646 mIU/mL

• 15 weeks: 12,540 - 69,747 mIU/mL

• 16 weeks: 8,904 - 55,332 mIU/mL

• 17 weeks: 8,240 - 51,793 mIU/mL

• 18 weeks: 9,649 - 55,271 mIU/mL

Normal value ranges may vary slightly among different laboratories. Talk to your health care provider about the meaning of your specific test result.

What Abnormal Results Mean

Higher than normal level may indicate:

• More than one fetus, for example, twins or triplets

• Choriocarcinoma of the uterus

• Hydatidiform mole of the uterus

• Ovarian cancer

• Testicular cancer (in men)

During pregnancy, lower than normal levels based on the gestational age may indicate:

• Fetal death

• Incomplete miscarriage

• Threatened spontaneous abortion (miscarriage)

• Ectopic pregnancy

Risks

Risks of having blood drawn are slight, but may include:

• Excessive bleeding

• Fainting or feeling lightheaded

• Blood accumulating under the skin (hematoma)

• Infection (a slight risk any time the skin is broken)

References

Jeelani R, Bluth MH. Reproductive function and pregnancy. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 24th ed. Philadelphia, PA: Elsevier; 2022:chap 26.

Lee P, Jain S, Pincus MR, et al. Diagnosis and management of cancer using serological and other body fluid markers. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 24th ed. Philadelphia, PA: Elsevier; 2022:chap 76.

Nerenz RD, Braga JA. Pregnancy and its disorders. In: Rifai N, Chiu RWK, Young I, Burnham Carey-Ann D, Wittwer CT, eds. Tietz Textbook of Laboratory Medicine. 7th ed. St Louis, MO: Elsevier; 2023:chap 59.

University of Iowa Diagnostic Laboratories. Test directory: HCG - serum, quantitative. www.healthcare.uiowa.edu/path_handbook/rhandbook/test446.html. Updated February 10, 2022. Accessed December 28, 2022.

Review Date: 11/10/2022

Reviewed By: John D. Jacobson, MD, Department of Obstetrics and Gynecology, Loma Linda University School of Medicine, Loma Linda, CA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.