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Fremanezumab-vfrm (By injection)

Fremanezumab-vfrm (free-ma-NEZ-ue-mab - vfrm)

Prevents migraine headaches.

Brand Name(s):

Ajovy

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not use it if you had an allergic reaction to fremanezumab-vfrm.

How to Use This Medicine:

Injectable

Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot under your skin.
A nurse or other health provider will give you this medicine.
You may be taught how to give your medicine at home. Make sure you understand all instructions before giving yourself an injection. Do not use more medicine or use it more often than your doctor tells you to.
This medicine is available in 2 forms: a prefilled autoinjector and a prefilled syringe.
You will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas. Do not inject into skin areas that are tender, red, bruised, callused, tattooed, hard, or has scars or stretch marks.
Allow 30 minutes for the autoinjector to warm up to room temperature. Do not warm using heat sources (including hot water, microwave, sunlight).
Check the liquid in the prefilled syringe and prefilled autoinjector. It should be clear and colorless to slightly yellow. Do not use it if it is cloudy, discolored, or has particles in it. Do not use it if it has been frozen, damaged, or has cracks or leaks. Do not shake.
Prefilled autoinjector:
- Wash your hands with soap and water before and after using this medicine.
- Hold the autoinjector and pull the protective cap straight off. Do not twist. Throw away the cap. Do not put it back on.
- Place the autoinjector against your skin at a 90 degree angle. Press down and keep holding it against the skin for about 30 seconds. You will hear the first "click" when the injection starts. You will hear a second "click" about 15 seconds after the first one, until the plunger moves to the bottom of the window. Wait for another 10 seconds to make sure you receive the full dose.
Prefilled syringe:
- Wash your hands with soap and water before and after using this medicine.
- Pull the needle cap straight off. Do not twist. Do not put the cap back on.
- Gently pinch the skin. Insert the needle at a 45 to 90 degree angle. Slowly push the plunger all the way down.
Use a new needle and syringe each time you inject your medicine.
Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
Missed dose: If you miss a dose of this medicine, use it as soon as you can. Then, continue to use it each month from the date of your last dose.
If you store this medicine at home, keep it in the refrigerator. Do not freeze. Keep the medicine in its original carton. You may store it at room temperature for up to 7 days. Do not return it to the refrigerator. Throw the medicine away if it has been left out of the refrigerator for more than 7 days.
Throw away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

Warnings While Using This Medicine:

Tell your doctor if you are pregnant or breastfeeding, or if you have high blood pressure or a history of blood vessel disease (including Raynaud's phenomenon).
This medicine may cause the following problems:
- Hypertension (high blood pressure)
- Raynaud's phenomenon, a blood circulation problem in the fingers or toes
Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Blurred vision, dizziness, headache, nervousness, pounding in the ears, slow or fast heartbeat
Sores, coldness, numbness, or color changes on your fingers or toes

If you notice these less serious side effects, talk with your doctor:

Pain, itching, burning, swelling, or a lump under your skin where the shot was given

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 5/4/2025