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Garadacimab-gxii (By injection)

Garadacimab-gxii (gar-a-DAK-i-mab - gxii)

Prevents hereditary angioedema (HAE) attacks.

Brand Name(s):

Andembry

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not use it if you had an allergic reaction to garadacimab-gxii.

How to Use This Medicine:

Injectable

  • Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot under your skin.
  • A nurse or other health provider will give you this medicine.
  • You may be taught how to give your medicine at home. Make sure you understand all instructions before giving yourself an injection. Do not use more medicine or use it more often than your doctor tells you to.
  • This medicine is available in 2 forms: a prefilled autoinjector or a prefilled syringe.
  • You will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas. This medicine is usually given in the upper arm, thigh, or stomach area (1 inch away from belly button). Do not inject into the belly button, moles, scars, or bruises, or into skin areas that are bruised, red, tender, or hard.
  • Allow 30 minutes for the medicine to warm up to room temperature. Do not warm it by using a heat source (including hot water, microwave, direct sunlight) or in any other way.
  • Check the liquid in the prefilled autoinjector or syringe. It should be brownish-yellow to yellow and slightly opalescent to clear. Do not use it if it is discolored or has particles in it. Do not use it if it looks damaged, has cracks, leaking, or has been dropped. Do not shake.
  • Prefilled autoinjector:
    • Wash your hands with soap and water before and after using this medicine.
    • Do not remove the cap until your are ready to inject.
    • Pull the cap straight off. Do not twist the clear cap. Do not put the cap back on. Do not touch the gray needle shield.
    • Gently pinch the skin. Place the autoinjector at a 90 degree angle. Press the gray needle shield firmly against the skin, you will hear a "click" which means the injection has started. The yellow plunger will start moving in the viewing window. You will head a second "click" after the first one. Keep pressing down for 5 more seconds to make sure you get the full dose. Make sure the yellow plunger completely fills the window and has stopped moving before removing the autoinjector.
    • The gray needle shield will return to its original position and will lock into place covering the needle.
  • Prefilled syringe:
    • Wash your hands with soap and water before and after using this medicine.
    • Do not remove the needle cap until your are ready to inject
    • Pull the needle cap straight off with one hand while holding the prefilled syringe with your other hand. Do not touch or hold the plunger. Do not recap the prefilled syringe. Do not touch the needle.
    • Gently pinch the skin. Fully insert the needle at an angle between 45 and 90 degrees. Do not change the angle during injection. Do not hold or push the plunger while inserting the needle into the skin.
    • Firmly push the plunger all the way down until it stops to get the full dose. Slowly remove the thumb from the plunger before removing the syringe from the skin. This will make the needle retract inside the syringe.
  • Use a new needle and syringe each time you inject your medicine.
  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
  • If you store this medicine at home, keep it in the refrigerator. Do not freeze. Keep it in its original container. Protect from light. Do not use it if it has been frozen or thawed. Do not put it back in the refrigerator after it has reached room temperature.
  • Throw away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

Warnings While Using This Medicine:

  • Tell your doctor if you are pregnant or breastfeeding.
  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

If you notice these less serious side effects, talk with your doctor:

  • Stomach pain
  • Stuffy or runny nose, sore throat
  • Pain, redness, or burning under your skin where the needle is placed

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 8/4/2025

 
 
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