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Gemcitabine (By injection)

Gemcitabine Hydrochloride

Treats bladder cancer.

Brand Name(s):

Inlexzo Intravesical System

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. You should not receive it if you had an allergic reaction to gemcitabine, or if you have a hole or tear in your bladder.

How to Use This Medicine:

Implant

  • Your doctor will prescribe your dose and schedule. This medicine is given into your bladder through a tube called a urinary catheter.
  • You will receive this medicine while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you this medicine.
  • Your doctor may give you other medicines (including antibiotics) before receiving or after removal of this medicine.
  • Do not empty your bladder before receiving this medicine.
  • After receiving this medicine:
    • Drink about 6 to 7 cups (1500 mL) of fluids per day during treatment with this medicine to make sure you have enough urine to be released into the bladder.
    • You can urinate normally. There is no need to hold your urine.
    • Avoid skin contact with your urine.
    • Male and female patients should sit on the toilet while urinating and flush after using.
    • Wash your hands well with soap and water and wash your genital area with water after you urinate.
    • Wash clothing soiled with urine right away and separately from any other clothing.
  • Avoid skin contact with your urine for at least 24 hours after this medicine is removed.
  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
  • Missed dose: This medicine needs to be given on a fixed schedule. If you miss a dose, call your doctor, home health caregiver, or treatment clinic for instructions.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

Warnings While Using This Medicine:

  • This medicine may cause birth defects if either partner is using it during conception or pregnancy. Tell your doctor right away if you or your partner becomes pregnant. If you can get pregnant, your doctor may do tests to make sure you are not pregnant before receiving this medicine. Use an effective form of birth control during treatment and for at least 6 months after the last dose. Male patients with female partners should use an effective form of birth control during treatment and for at least 3 months after the last dose.
  • Do not breastfeed during treatment and for 1 week after the last dose.
  • Tell your doctor if you have kidney disease.
  • Some men who use this medicine have become infertile (unable to have children). Talk with your doctor before using this medicine if you plan to have children.
  • Your doctor will give you an MRI safety information card. This card contains important information in case you need to have an MRI. Keep the card and show it to all of your healthcare professionals before you have an MRI.
  • Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Bloody or cloudy urine, lower back or side pain, painful or difficult urination
  • Change in how much or how often you urinate

If you notice these less serious side effects, talk with your doctor:

  • Diarrhea
  • Tiredness

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 11/4/2025

 
 
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